منابع مشابه
Site-specific Drug Delivery: Polymers for Gastroretention
Gastroretention is the mechanism by which a dosage form is retained in the stomach, generally for the purposes of improving drug delivery. It has been proposed as a mechanism through which drug absorption in the upper gastrointestinal tract can be maximised. Gastroretentive approaches to drug delivery aim to counteract the physiological mechanisms that cause the stomach to empty by providing a ...
متن کاملPrecision Medicine and Site-Specific Drug Delivery
Precision medicine is an approach to prevent and treat diseases that takes into account people’s individual variations in genes, environment, and lifestyle. The current Precision Medicine Initiative of the US Government is to “generate the scientific evidence needed to move the concept of precision medicine into clinical practice”. In the first approximation, precision medicine may provide a mo...
متن کاملSite-specific drug delivery in the gastrointestinal tract.
In recent years there has been a significant increase in available strategies for site-specific delivery in the gastrointestinal tract both to maximize a therapeutic response and to reduce side effects. However, in only a few instances has there been close attention paid to how these products will perform in the heterogeneous environment of the human gut. Targeted oral delivery requires a multi...
متن کاملFrom systemic shotgun to site-specific nanoparticle-targeted delivery: a new paradigm for drug delivery.
Since the introduction of percutaneous techniques for the relief of symptomatic obstructive atherosclerotic coronary artery disease in the late 1970s, the major Achilles heel was restenosis. After nearly 3 decades of study, the cellular and molecular biology of this complex response to injury is now far better understood and includes the role of thrombosis, cellular proliferation, inflammation,...
متن کاملProgrammable drug release using bioresponsive mesoporous silica nanoparticles for site-specific oral drug delivery.
Novel mesoporous silica nanoparticles (MSNs) responsive to multiple biological stimuli (pH and enzymes) were prepared through conjugation with a structure modified soy protein isolate. The particles show an extremely high pro-drug (sulfasalazine) loading with programmable drug release in simulated gastrointestinal fluid.
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1987
ISSN: 0014-5793
DOI: 10.1016/0014-5793(87)80461-1